Effects of ozone administration
on cerebral and hepatic tissue metabolism in hemorrhagic shock
Department of Anesthesiology, Nihon University
ISSN: 0546-0352
Journal written in English.
CAN 132:306600
Abstract
Ozone is believed
to have an activating effect on tissue metab.
Hemorrhagic shock was therefore induced exptl. in rabbits, and the
effects of an ozonized soln. on the tissue energy metab. were
investigated in the brain and liver, organs with different energy sources. When ozone was administered, the ATP and
energy charge in the brain and liver increased significantly, indicating that
ozone is able to maintain the energy metab. of the tissue,
regardless of the energy source.
Hypoxanthine is a cleavage product of ATP that is produced during
ischemia. When ozone was administered,
the level of hypoxanthine decreased significantly in the brain and liver,
showing that ATP prodn. was sufficiently
maintained. The present results for
ozone administration using a hemorrhagic shock model suggest that ozone can
activate the tissue energy metab., regardless of the
energy source.