Mechanisms of action of ozone in maintaining energy
metabolism in hemorrhagic shock
Akioka, Kenichiro; Shiratori, Rinji; Kaneko,
Yoshiro; Ogawa, Setsuro.
Department of Anesthesiology, Nihon University
ISSN: 0546-0352.
Journal
written in English.
CAN 139:207403
Abstract
The pathol. condition
created by oxygen administration and fluid resuscitation in hemorrhagic shock
treatment is considered as a global ischemia-reperfusion injury and the free
radicals produced during shock play an important role. When an ozonated soln. was administered, the
results revealed that energy metab. was activated and
maintained. In the present study, we
focused on the prodn. of glutathione involved in the pentose
phosphate pathway which is a part of the mechanism of action of ozone in
maintaining tissue energy metab. and also the cellular
protective action of glutathione in maintaining its reduced state and removing
active oxygen. The
mechanism of action of ozone in maintaining tissue energy metab. was investigated in relation to the glutathione system. The results demonstrated significant
increases in GSH and GSSG when blood was withdrawn. There were no significant differences in GSH
and GSSG between the Salinehes group and the ozonated Salinehes group at 50 min
after blood withdrawal. However, the GSH
and GSSG values in the ozonated Salinehes group tended to reveal lower
values. Concerning the
action in maintaining energy metab. in
hemorrhagic shock, it is suggested therefore that the administration of an
ozonated soln. may be involved via the pentose phosphate pathway.